Pair Name	Berbamine, Sorafenib
Disease Info	[ICD-11: 2C12]	Hepatocellular carcinoma		Investigative
Biological Phenomena	Target-->Na(+)/K(+)-ATPase
Gene Regulation	Down-regulation	Expression	MYC	hsa4609
	Down-regulation	Expression	CCND1	hsa595
	Up-regulation	Phosphorylation	MAPK14	hsa1432
	Up-regulation	Phosphorylation	MAPK1	hsa5594
	Up-regulation	Phosphorylation	EGFR	hsa1956
	Up-regulation	Phosphorylation	IGF1R	hsa3480
	Up-regulation	Phosphorylation	SRC	hsa6714
	Down-regulation	Expression	MCL1	hsa4170
	Up-regulation	Cleavage	PARP1	hsa142
	Up-regulation	Cleavage	CASP3	hsa836
In Vitro Model	Hep-G2	Hepatoblastoma	Homo sapiens (Human)	CVCL_0027
	SK-HEP-1	Liver and intrahepatic bile duct epithelial neoplasm	Homo sapiens (Human)	CVCL_0525
In Vivo Model	5×10⁶ HepG2 cells in 200 μl PBS were subcutaneously injected into the mice at 6 weeks of age.
Result	Targeting Na+/K+-ATPase by berbamine and ouabain synergizes with sorafenib to inhibit hepatocellular carcinoma

Pair Name	Berbamine, Sorafenib
Disease Info	[ICD-11: 2C12]	Hepatocellular carcinoma		Investigative
Biological Phenomena	Induction-->Apoptosis
Gene Regulation	Down-regulation	Phosphorylation	RB1	hsa5925
	Down-regulation	Expression	CCND1	hsa595
	Down-regulation	Expression	CDK4	hsa1019
	Down-regulation	Expression	CDK6	hsa1021
	Up-regulation	Cleavage	PARP1	hsa142
	Up-regulation	Cleavage	CASP3	hsa836
	Down-regulation	Expression	BCL2	hsa596
	Down-regulation	Phosphorylation	STAT3	hsa6774
In Vitro Model	HCCLM3	Adult hepatocellular carcinoma	Homo sapiens (Human)	CVCL_6832
	L-02	Papillomavirus-related cervical adenocarcinoma	Homo sapiens (Human)	CVCL_6926
Result	These findings identify a new type of natural STAT3 inhibitor and provide a novel approach to the enhancement of SORA efficacy by blocking the activation of STAT3.